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4-(4-CHLORO-2-METHYLPHENYL)-4-OXOBUTYRIC ACID synthesis

2synthesis methods
14495-51-3 Synthesis
1-Bromo-4-chloro-2-methylbenzene

14495-51-3
249 suppliers
$10.00/5g

4-(4-CHLORO-2-METHYLPHENYL)-4-OXOBUTYRIC ACID

91193-36-1
9 suppliers
inquiry

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Yield:-

Steps:

Multi-step reaction with 2 steps
1: magnesium; iodine / tetrahydrofuran / 0.5 h / 20 - 60 °C
2: tetrahydrofuran / 0.5 h / 20 °C

References:

WO2016/23877,2016,A1