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ChemicalBook CAS DataBase List 4-(4-CHLOROBENZYL)PYRIDINE
4409-11-4

4-(4-CHLOROBENZYL)PYRIDINE synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 50 °C / Inert atmosphere
1.2: 2 h / -50 °C / Inert atmosphere
2.1: palladium(II) trifluoroacetate; tricyclohexylphosphine; caesium carbonate / o-xylene / 6 h / Inert atmosphere; Reflux

References:

Jin, Weiwei;Zheng, Poonnapa;Wong, Wing-Tak;Law, Ga-Lai [Advanced Synthesis and Catalysis,2017,vol. 359,# 9,p. 1588 - 1593]

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