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4-(4-Chlorophenyl)-2-methylbut-1-ene synthesis

2synthesis methods
-

Yield:106897-78-3 99%

Reaction Conditions:

Stage #1: 3-Chloro-2-methylpropenewith magnesium in tetrahydrofuran at 0 - 20;Inert atmosphere;
Stage #2: 4-chlorobenzyl bromide in tetrahydrofuran at 0 - 20;Inert atmosphere;

References:

Watanabe, Eiichi;Kaiho, Atsushi;Kusama, Hiroyuki;Iwasawa, Nobuharu [Journal of the American Chemical Society,2013,vol. 135,# 32,p. 11744 - 11747] Location in patent:supporting information