4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBONITRILE synthesis

3synthesis methods

Product Name:4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBONITRILE
CAS Number:91721-16-3
Molecular formula:C12H13ClN2
Molecular Weight:220.7

218451-34-4 Synthesis

TERT-BUTYL 4-(4-CHLOROPHENYL)-4-CYANOPIPERIDINE-1-CARBOXYLATE

218451-34-4
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4-(4-CHLOROPHENYL)PIPERIDINE-4-CARBONITRILE

91721-16-3
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Yield:91721-16-3 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 72 h;

Steps:

30.e e) 4-(4-chlorophenyl)-4-cyanopiperidine

e) 4-(4-chlorophenyl)-4-cyanopiperidine. A solution containing 1-N-Boc-4-(4-chlorophenyl)-4-cyanopiperidine (1.32 g, 4.11 mmol), TFA (11 mL), and DCM (11 mL) was stirred at RT for 72 h, and then concentrated. The residue was treated with water and sat. aq. sodium bicarbonate (until basic), then extracted with DCM (3X). The DCM extracts were dried (Na2SO4), filtered, and concentrated to give the title compound (quant. ) as a colored oil. MS m/z 221 (M+H).

References:

WO2004/22539,2004,A1 Location in patent:Page 34

4-Piperidinecarbonitrile, 4-(4-chlorophenyl)-1-[(3,4-dimethoxyphenyl)methyl]-

644981-92-0
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91721-16-3
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References

821-48-7 Synthesis

821-48-7
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140-53-4
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91721-16-3
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References