4,4-Dimethyl-7-ethynyl-1-tetralone synthesis

3synthesis methods

Product Name:4,4-Dimethyl-7-ethynyl-1-tetralone
CAS Number:166978-48-9
Molecular formula:C14H14O
Molecular Weight:198.26

1(2H)-Naphthalenone, 3,4-dihydro-4,4-diMethyl-7-[(triMethylsilyl)ethynyl]-

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166978-48-9
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Yield:166978-48-9 694 mg (Y: 76%)

Reaction Conditions:

with potassium carbonate in ethanol;hexane;

Steps:

97 4,4-Dimethyl-7-ethynyl-1-tetralone (L)

EXAMPLE 97 4,4-Dimethyl-7-ethynyl-1-tetralone (L) To a solution of compound IL (1.24 g, 4.59 mmol), in absolute ethyl alcohol (8.0 mL) was added anhydrous potassium carbonate (170 mg, 1.21 mmol) at room temperature. After 2 h the reaction mixture was concentrated in vacuo, diluted with saturated sodium bicarbonte (25 mL) and extracted with methylene chloride (2*25 mL). The organic phases were combined, concentrated in vacuo and the residue chromatographed on silica gel (eluted with 5% ethyl acetate in hexane) to give 694 mg (Y: 76%) of the title product; ¹ H-NMR (CDCl₃): δ8.15 (d, J=1.9 Hz, 1H), 7.62 (dd, J=8.2, 1.9 Hz, 1H), 7.39 (d, J=8.2 Hz, 1H), 3.07 (s, 1H), 2.73 (t, J=7.0 Hz, 2H), 2.02 (t, J=7.0 Hz, 2H), 1.39 (s, 6H); MS (DCI) m/e: 199 (MH⁺).

References:

US5618839,1997,A

2979-69-3 Synthesis

4,4-DIMETHYL-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE

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166978-48-9
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References

7-BROMO-4,4-DIMETHYL-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE

166978-46-7
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166978-48-9
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$95.00/25mg

References