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ChemicalBook CAS DataBase List 4-(4-FLUORO-PHENOXY)-BENZENESULFONYL CHLORIDE

4-(4-FLUORO-PHENOXY)-BENZENESULFONYL CHLORIDE synthesis

2synthesis methods
-

Yield:192329-91-2 88%

Reaction Conditions:

Stage #1: 4-fluorophenoxybenzenewith chlorosulfonic acid in dichloromethane;
Stage #2: with thionyl chloride in N,N-dimethyl-formamide;

References:

Ginsel, Carsten;Plitzko, Birte;Froriep, Danilo;Stolfa, Diana A.;Jung, Manfred;Kubitza, Christian;Scheidig, Axel J.;Havemeyer, Antje;Clement, Bernd [Drug Metabolism and Disposition,2018,vol. 46,# 10,p. 1396 - 1402] Location in patent:supporting information