4-(4-FLUORO-PHENYL)-PIPERIDINE synthesis
- Product Name:4-(4-FLUORO-PHENYL)-PIPERIDINE
- CAS Number:37656-48-7
- Molecular formula:C11H14FN
- Molecular Weight:179.23
163630-89-5
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37656-48-7
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Yield:37656-48-7 94%
Reaction Conditions:
with H2;Pd(OH)2 in methanol;
Steps:
b b.
b. 4-(4-fluoro)-phenyl-piperidine To a solution of 1-benzyl-4-(4-fluoro-phenyl)-1,2,3,6-tetrahydro-pyridine (45.0 mmol, 12.0 g) in 100 mL MeOH was added 1.0 g of Pd(OH)2 and the resulting suspension was hydrogenated under 200 psi of H2 in a stainless steel bomb for two days. The suspension was passed through a pad of celite and the filtrate was concentrated in vacuo to obtain 4-(4-fluoro)-phenyl-piperidine (7.5 g, 94%) as a viscous oil.
References:
US6218390,2001,B1
183950-95-0
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37656-48-7
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$22.00/250mg
1978-61-6
52 suppliers
$45.00/50mg
37656-48-7
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$22.00/250mg
163631-01-4
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37656-48-7
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7440-05-3
469 suppliers
$17.69/1G
1978-61-6
52 suppliers
$45.00/50mg
37656-48-7
109 suppliers
$22.00/250mg