4-(4-FLUOROBENZYL)-4-HYDROXYPIPERIDINE HCL synthesis

Yield:1429505-77-0 93.2%

Reaction Conditions:

with hydrogenchloride in methanol at 25; for 1 h;

Steps:

3.2 Step 2

To tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate (1.5 g, 4.84 mmol) was added 4M HCl in MeOH (20 mL) at 25^oC. The reaction mixture was stirred at 25^oC for 1 hour, and the reaction mixture was concentrated to give 4-(4-fluorobenzyl)piperidin-4-ol hydrochloride (1.1 g, 93.2%).¹H-NMR (400 MHz, MeOD) δ_H7.41-7.18 (m, 2H), 7.15-6.90 (m, 2H), 3.30-3.10 (m, 5H), 2.90-2.65 (m, 2H), 2.05-1.88 (m, 1H), 1.86-1.72 (m, 2H), 1.71-1.60 (m, 2H).

References:

WO2022/115620,2022,A1 Location in patent:Paragraph 0271; 0274-0275