4-(4-FLUOROPHENOXY)BUTANOIC ACID synthesis

5synthesis methods

Product Name:4-(4-FLUOROPHENOXY)BUTANOIC ACID
CAS Number:1549-77-5
Molecular formula:C10H11FO3
Molecular Weight:198.19

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Yield:1549-77-5 52.7%

Steps:

40 (Synthesis of 4-(4-fluorophenoxy)butyric acid)

The resulting crude 4-(4-fluorophenoxy)butyric acid (precipitate) was dissolved in a small amount of hot methanol, and gradually cooled to recrystallize. Filtrated recrystallization materials were dried by vacuum pump to provide objective compound, 4-(4-fluorophenoxy)butyric acid. In this series of processes, the resulting 4-(4-fluorophenoxy)butyric acid was 52.7% in yield based on the raw material 4-bromoethylbutyrate. In order to verify that the resulting compound was the objective 4-(4-fluorophenoxy)butyric acid, NMR analysis was carried out by the following measuring apparatus under measuring condition to identify thestructure.

References:

EP1113033,2001,A2

371-41-5 Synthesis