[4-(4-fluorophenoxy)phenyl]methanol synthesis
- Product Name:[4-(4-fluorophenoxy)phenyl]methanol
- CAS Number:167091-96-5
- Molecular formula:C13H11FO2
- Molecular Weight:218.22
137736-06-2
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167091-96-5
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$174.00/1g
Yield: 65.9%
Reaction Conditions:
with methanol;sodium tetrahydroborate at 20;
Steps:
D69: (4-(4-fluorophenoxy)phenTo a solution of 4-(4-fluorophenoxy)benzaldehyde (10 g, 46.3 mmol) in methanol (50 mL) was added NaBH4 (1.750 g, 46.3 mmol) portionwise, after addition the mixture was stirred at room temperature overnight. After removing the solvent, the residue was diluted with DCM (50 mL), the suspension was filtered though a pad of Celite, the filtrate was concentrated to afford the title compound (7 g, 30.5 mmol, 65.9 % yield) as a gray solid. LCMS: rt = 1.49 min, [M+H+] = 219
References:
GLAXO GROUP LIMITED;JIN, Yun;WAN, Zehong;ZHANG, Qing WO2012/76435, 2012, A1 Location in patent:Page/Page column 47
371-41-5
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167091-96-5
18 suppliers
$174.00/1g
459-57-4
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167091-96-5
18 suppliers
$174.00/1g