4-(4-Isopropoxyphenyl)cyclohexanone synthesis

3synthesis methods

Product Name:4-(4-Isopropoxyphenyl)cyclohexanone
CAS Number:365553-47-5
Molecular formula:C15H20O2
Molecular Weight:232.32

75-30-9
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105640-07-1
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365553-47-5
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$32.00/100mg

Yield:365553-47-5 95%

Reaction Conditions:

with potassium carbonate in water;N,N-dimethyl-formamide;

Steps:

5.1 Step 1

Step 1 A solution of 4-(4-hydroxyphenyl)cyclohexanone (6.0 g, 31.6 mmol) in DMF (90 mL) was treated with K₂CO₃ (21 g, 158 mmol, 5 equiv) and 2-iodopropane (15 mL, 26.8 g, 158 mmol, 5 equiv.). The reaction was heated at 100° C. overnight. After the solvent was removed, the residue was treated with H₂O and extracted with EtOAc. The organic extracts were combined and washed with brine, dried over Na₂SO₄ and concentrated in vacuum to give the spectroscopically pure 4-(4-isopropoxyphenyl)cyclohexanone (7.02 g, 95%). ¹H NMR (CDCl₃): 7.14 (dt, 2H), 6.84 (dt, 2H), 4.3 (septet, 1H), 2.97 (tt, 1H), 2.46-2.52 (m, 4H), 2.16-2.24 (m, 2H), 1.83-1.98 (m, 2H) and 1.33 (d, 6H).

References:

US2002/143141,2002,A1

1,4-Dioxaspiro[4.5]decane, 8-[4-(1-methylethoxy)phenyl]-

868141-71-3
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365553-47-5
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References

1,4-Dioxaspiro[4.5]decan-8-ol, 8-[4-(1-methylethoxy)phenyl]-

868141-41-7
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365553-47-5
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$32.00/100mg

References