4-(4-ISOPROPYLPIPERAZIN-1-YL)BENZALDEHYDE synthesis

3synthesis methods

Product Name:4-(4-ISOPROPYLPIPERAZIN-1-YL)BENZALDEHYDE
CAS Number:197638-78-1
Molecular formula:C14H20N2O
Molecular Weight:232.32

4318-42-7 Synthesis

4318-42-7
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459-57-4 Synthesis

459-57-4
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4-(4-ISOPROPYLPIPERAZIN-1-YL)BENZALDEHYDE

197638-78-1
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$303.00/100mg

Yield:197638-78-1 84%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide;Reflux;

Steps:

3.1.1. Synthesis of 4-Substituted Benzaldehydes 1a-1d

General procedure: A solution of 4-fluorobenzaldehyde (0.017 mol, 1.82 mL) and an appropriate secondary aminein DMF (10 mL) was refluxed (0.017 mol) in the presence of potassium carbonate (K2CO3, 0.017 mol,2.35 g). After completion of reaction, the mixture was cooled with ice-water (10 mL) and extractedwith ethyl acetate (3 20 mL). The ethyl acetate phases were combined, and the remaining productwas collected after evaporation of the solvent. The following compounds were prepared in this way:4-(4-methylpiperazin-1-yl)benzaldehyde (1a), CAS No:27913-99-1, Yield 82%, m.p. = 55-57 °C (measured),m.p. = 58-60 °C (reported) [60]; 4-(4-ethylpiperazin-1-yl)benzaldehyde (1b), CAS No:197638-76-9,Yield 79%, obtained as an oil; 4-(4-isopropylpiperazin-1-yl)benzaldehyde (1c), CAS No:197638-78-1,Yield 84%, obtained as an oil and 4-(4-cylopropylpiperazin-1-yl)benzaldehyde (1d), CAS No:1292778-23-4,Yield 78%, obtained as an oil.

References:

Tokg?z, Gamze;?zkay, ümide Demir;Osmaniye, Derya;Yücel, Nazl? Turan;Can, ?zgür Devrim;Kaplanc?kl?, Zafer As?m [Molecules,2018,vol. 23,# 11,art. no. 2881]

Benzonitrile, 4-[4-(1-methylethyl)-1-piperazinyl]-

186650-79-3
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197638-78-1
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References

68104-63-2 Synthesis

68104-63-2
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197638-78-1
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$303.00/100mg

References