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ChemicalBook CAS DataBase List 4-(4-Oxocyclohexyl)benzoic acid
137465-01-1

4-(4-Oxocyclohexyl)benzoic acid synthesis

3synthesis methods
73204-07-6 Synthesis
4-(4-OXOCYCLOHEXYL)BENZONITRILE

73204-07-6
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Yield:137465-01-1 81.8%

Reaction Conditions:

with lithium hydroxide monohydrate;potassium hydroxide in methanol at 70; for 3 h;

Steps:

D124.1; D125.1 Step 1: 4- (4-oxocyclohexyl) benzoic acid

To a solution of 4- (4-oxocyclohexyl) benzonitrile (5 g, 25.1 mmol) and KOH (5.6 g, 100.4 mmol) in MeOH: H2O =20: 1 (100 mL), the mixture was stirred at70 for 3h. TLC (EA, Rf =0.5) showed the reaction was completed. Filtered and concentrated, H2O (100 ml) was was added and extracted with DCM (50 ml3). The combined organic layer was dried over Na2SO4, filtered and concentrated to give product (4.5 g, 81.8%) as a white solid.

References:

WO2018/54365,2018,A1 Location in patent:Paragraph 0617; 0618