4-(4-Oxocyclohexyl)benzoic acid synthesis
- Product Name:4-(4-Oxocyclohexyl)benzoic acid
- CAS Number:137465-01-1
- Molecular formula:C13H14O3
- Molecular Weight:218.25
73204-07-6
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137465-01-1
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Yield:137465-01-1 81.8%
Reaction Conditions:
with lithium hydroxide monohydrate;potassium hydroxide in methanol at 70; for 3 h;
Steps:
D124.1; D125.1 Step 1: 4- (4-oxocyclohexyl) benzoic acid
To a solution of 4- (4-oxocyclohexyl) benzonitrile (5 g, 25.1 mmol) and KOH (5.6 g, 100.4 mmol) in MeOH: H2O =20: 1 (100 mL), the mixture was stirred at70 for 3h. TLC (EA, Rf =0.5) showed the reaction was completed. Filtered and concentrated, H2O (100 ml) was was added and extracted with DCM (50 ml3). The combined organic layer was dried over Na2SO4, filtered and concentrated to give product (4.5 g, 81.8%) as a white solid.
References:
WO2018/54365,2018,A1 Location in patent:Paragraph 0617; 0618
137465-00-0
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137465-01-1
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52787-14-1
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137465-01-1
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