ChemicalBook CAS DataBase List 4-(4-Oxocyclohexyl)benzoic acid

4-(4-Oxocyclohexyl)benzoic acid synthesis

3synthesis methods

Product Name:4-(4-Oxocyclohexyl)benzoic acid
CAS Number:137465-01-1
Molecular formula:C13H14O3
Molecular Weight:218.25

73204-07-6 Synthesis

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Yield:137465-01-1 81.8%

Reaction Conditions:

with lithium hydroxide monohydrate;potassium hydroxide in methanol at 70; for 3 h;

Steps:

D124.1; D125.1 Step 1: 4- (4-oxocyclohexyl) benzoic acid

To a solution of 4- (4-oxocyclohexyl) benzonitrile (5 g, 25.1 mmol) and KOH (5.6 g, 100.4 mmol) in MeOH: H2O =20: 1 (100 mL), the mixture was stirred at70 for 3h. TLC (EA, Rf =0.5) showed the reaction was completed. Filtered and concentrated, H2O (100 ml) was was added and extracted with DCM (50 ml3). The combined organic layer was dried over Na2SO4, filtered and concentrated to give product (4.5 g, 81.8%) as a white solid.

References:

WO2018/54365,2018,A1 Location in patent:Paragraph 0617; 0618

1,3-Cyclohexanedicarboxylic acid, 1-[4-(methoxycarbonyl)phenyl]-4-oxo-, 1,3-dimethyl ester

137465-00-0
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References

4-METHOXYCARBONYLMETHYL-BENZOIC ACID METHYL ESTER

52787-14-1
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137465-01-1
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References