4,4-piperidinediyldimethanol(SALTDATA: HCl) synthesis

2synthesis methods

Product Name:4,4-piperidinediyldimethanol(SALTDATA: HCl)
CAS Number:848070-24-6
Molecular formula:C7H15NO2
Molecular Weight:145.2

4,4-Bis(hydroxymethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

374794-84-0
36 suppliers
inquiry

4,4-piperidinediyldimethanol(SALTDATA: HCl)

848070-24-6
18 suppliers
$270.00/1g

Yield:848070-24-6 99%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

A.13.3

(4-Hydroxymethyl-piperidin-4-yl)-methanol To a solution OF 4, 4-BIS-HYDROXYMETHYL-PIPERIDINE-L-CARBOXYLIC acid tert- butyl ester (1.02 g) in dichloromethane (20 mL) was added trifluoroacetic acid (10 ML), and the reaction was allowed to sit for an hour at room temperature. The solvent was then removed in vacuo, and the residue was azeotrope with methanol. The amine was freebased by stirring in hydroxy resin/methanol/ tetrahydrofuran for 30 minutes. The slurry was filtered and the filtrate concentrated to yield 4, 4-Bis-hydroxymethyl piperidine as an oil (0.6 g, 99% yield).

References:

WO2005/26145,2005,A2 Location in patent:Page/Page column 115

diethyl 1-benzylpiperidine-4,4-dicarboxylate

765962-22-9
3 suppliers
inquiry

848070-24-6
18 suppliers
$270.00/1g

References