4-[4-(THIEN-2-YLCARBONYL)PIPERAZIN-1-YL]ANILINE synthesis
- Product Name:4-[4-(THIEN-2-YLCARBONYL)PIPERAZIN-1-YL]ANILINE
- CAS Number:412331-95-4
- Molecular formula:C15H17N3OS
- Molecular Weight:287.38
330468-37-6
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Yield:412331-95-4 100%
Reaction Conditions:
with hydrogenchloride;palladium 10% on activated carbon;hydrogen in methanol;water at 20; for 5 h;
Steps:
4.10. General procedure for catalytic hydrogenation of nitro group for synthesis of 8i and 8j
General procedure: 4-Nitrophenylpiperazine (7a or 7b) and 10% Pd/C was mixed in methanol (10 mL) containing concentrated HCl (2 mL). Hydrogen gas was then pumped into the mixture at RT. After stirring the solution for 5 h, the catalyst was filtered on Celite and the organic filtrate concentrated in vacuo to afford the corresponding aniline derivative (8h and 8j) in ～100% yield. The full spectral characterization of these products is provided as Supplementary Information.
References:
Al-Horani, Rami A.;Mehta, Akul Y.;Desai, Umesh R. [European Journal of Medicinal Chemistry,2012,vol. 54,p. 771 - 783] Location in patent:supporting information; experimental part
527-72-0
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6269-89-2
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