ChemicalBook CAS DataBase List 4-(4H-1,2,4-TRIAZOL-4-YL)BENZOIC ACID

4-(4H-1,2,4-TRIAZOL-4-YL)BENZOIC ACID synthesis

5synthesis methods

Product Name:4-(4H-1,2,4-TRIAZOL-4-YL)BENZOIC ACID
CAS Number:157069-48-2
Molecular formula:C9H7N3O2
Molecular Weight:189.17

4-(4H-1,2,4-TRIAZOL-4-YL)-BENZOIC ACID, ETHYL ESTER

167626-25-7
2 suppliers
inquiry

157069-48-2
78 suppliers
$22.00/100mg

Yield: 99%

Reaction Conditions:

Stage #1:4-(4H-1,2,4-triazol-4-yl)benzoic acid ethyl ester with water;sodium hydroxide in ethanol for 0.5 h;Reflux;
Stage #2: with hydrogenchloride in water

Steps:

88
Ester 124 (6.8 g, 31.3 mmol) was dispersed into ethanol (70 ml), 1N sodium hydroxide (70 ml) was added, heated and refluxed for 30 minutes. After reaction ended, the solvent was distilled in vacuum, and the residu obtained was dissolved in water. 1N hydrochloric acid (70 ml) was added, precipitated colorless solid was filtered out, washed with water and dried in vacuum, yielding 125 (5.88 g, 99%). > mp330°C APCI-MS m/z 190[M+H]⁺ IR(Nujol) 1692, 1609cm^-1

References:

Tohoku University EP2103611, 2009, A1 Location in patent:Page/Page column 83