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151129-10-1

4-(5,6,7,8-Tetrahydroquinolin-2-yl)benzonitrile synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 60 percent / trans-BnPd(PPh3)2Cl / CHCl3 / 2 h / Heating
2: 75 percent / SnCl2; TMSCl / CH2Cl2 / 2 h / -78 - 20 °C
3: 42 percent / NH4OAc / acetic acid / Heating

References:

Kelly, T. Ross;Lebedev, Rimma L. [Journal of Organic Chemistry,2002,vol. 67,# 7,p. 2197 - 2205]