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4-(5-Chloropyridin-2-yl)morpholine synthesis

2synthesis methods
110-91-8 Synthesis
Morpholine

110-91-8
676 suppliers
$9.00/1g

40473-01-6 Synthesis
2-Bromo-5-chloropyridine

40473-01-6
420 suppliers
$5.00/1g

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Yield:59027-83-7 78%

Reaction Conditions:

with dichloro[4,5-bis(diphenylphosphino)-9,9’-dimethylxanthene]palladium(II);sodium t-butanolate at 75;Inert atmosphere;Buchwald-Hartwig Coupling;

References:

Bourriquen, Florian;Bruneau-Voisine, Antoine;Jeandin, Aliénor;Stihle, Etienne;Fantasia, Serena [Chemistry - A European Journal,2019,vol. 25,# 38,p. 9006 - 9011] Location in patent:supporting information