4,5-DiaMino-2-fluorobenzonitrile synthesis
- Product Name:4,5-DiaMino-2-fluorobenzonitrile
- CAS Number:226701-59-3
- Molecular formula:C7H6FN3
- Molecular Weight:151.14
Yield:-
Reaction Conditions:
with sulfuric acid;potassium nitrate
Steps:
1 4,5-Diamino-2-fluorobenzonitrile
Example 1 4,5-Diamino-2-fluorobenzonitrile A mixture of potassium nitrate (73.2 g, 0.718 mmol, 2 eq) and concentrated sulfuric acid (350 mL) was cooled to 0° C. and 2,4-difluorobenzonitrile was added in portions over 10 to 15 minutes. The mixture was stirred for 30 minutes and then poured onto ice to give a precipitate. The precipitate was isolated by filtration, washed with water and lyophilized to provide 2,4-difluoro-5-nitrobenzonitrile (50 g, 0.28 mol) as an off-white solid; PB-CI/MS: 185=(MH+); 1 H-NMR (300 Mhz, DMSO-d6): 8.093(t, 1H), 8.982(t, 1H).
References:
Axys Pharmaceuticals, Inc. US6150379, 2000, A
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