ChemicalBook CAS DataBase List 4,5-DIAMINO-2-FLUOROBENZOTRIFLUORID

4,5-DIAMINO-2-FLUOROBENZOTRIFLUORID synthesis

7synthesis methods

Product Name:4,5-DIAMINO-2-FLUOROBENZOTRIFLUORID
CAS Number:179062-06-7
Molecular formula:C7H6F4N2
Molecular Weight:194.13

5-AMINO-2-FLUORO-4-NITROBENZOTRIFLUORIDE

179062-05-6
61 suppliers
$21.00/1g

179062-06-7
52 suppliers
$54.00/100mg

Yield:179062-06-7 95%

Reaction Conditions:

palladium-carbon in ethanol;

Steps:

83.D D.

D. 3,4-Diamino-6-fluorobenzotrifluoride A mixture of 3-amino-6-fluoro-4-nitrobenzotrifluoride (328 mg, 1.45 mmol) and 10% Pd/C (50 mg) in ethanol (15 mL) was hydrogenated for 2 h at 25° C. under 25 psi H₂. The catalyst was removed by filtration with celite and the solvent was removed by rota-evaporation to give 270 mg of 3,4-diamino-6-fluorobenzotrifluoride (95%) as a brown solid. ¹ H NMR (CDCl₃): δ3.432 (br, 4H), 6.469 (d, 1H, J=8.4 Hz); 6.860 (d, 1H, J=6.6 Hz).

References:

US5514680,1996,A