4,5-DibroMo-Furan-2-Carboxylic Acid Ethyl Ester synthesis
- Product Name:4,5-DibroMo-Furan-2-Carboxylic Acid Ethyl Ester
- CAS Number:54113-42-7
- Molecular formula:C7H6Br2O3
- Molecular Weight:297.93
2434-03-9
95 suppliers
$7.00/250mg
64-17-5
728 suppliers
$10.00/50g
54113-42-7
18 suppliers
$28.60/50MG
Yield:54113-42-7 97%
Reaction Conditions:
with sulfuric acid in ethanol;Reflux;
Steps:
2A ethyl 4,5-dibromofuran-2-carboxylate
25.0 g (92.6 mmol) of 4,5-dibromofuran-2-carboxylic acid are provided in 250 ml of ethanol, 4.9 ml (92.6 mmol) of sulfuric acid (98%) are added and the mixture is heated under reflux overnight. The reaction mixture is concentrated, and a saturated aqueous sodium bicarbonate solution is added to the residue until a basic pH is established. The precipitate is collected by suction filtration, washed with water and dried under high vacuum. 26.9 g (97% of theory) of the title compound are obtained.1H-NMR (400 MHz, DMSO-d6): δ=7.62 (s, 1H), 4.30 (q, 2H), 1.29 (t, 3H).LC-MS (Method 1): Rt=2.43 min; MS (ESIpos): m/z=297 [M+H]+.
References:
US2012/22059,2012,A1 Location in patent:Page/Page column 11
2434-03-9
95 suppliers
$7.00/250mg
54113-42-7
18 suppliers
$28.60/50MG