4.5-DICHLORO-4,5,5-TRIFLUORO-1-PENTANOL synthesis
- Product Name:4.5-DICHLORO-4,5,5-TRIFLUORO-1-PENTANOL
- CAS Number:97915-27-0
- Molecular formula:C5H7Cl2F3O
- Molecular Weight:211.01
1869-18-7
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97915-27-0
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Yield:97915-27-0 86.5%
Reaction Conditions:
with tri-n-butyl-tin hydride at 0 - 20; for 3.5 h;
Steps:
5.b [0215] b) Reduction of 2-iodo-4,5,5-trifluoro-4,5-dichloropentanol
[0216] 80.0 g (0.27 mol) of tributyltin hydride were added dropwise with stirring to 88.9 g (0.26 mol) of 2-iodo-4,5,5-trifluoro-4,5-dichloropentanol placed in a flask, saturated with argon and equipped with a septum, cooled in an ice bath. The addition took 30 minutes, the ice bath having been gradually reduced. The mixture was then stirred for an additional 3 hours at ambient temperature. Subsequently, the reduced derivative, 4,5-dichloro-4,5,5-trifluoropentanol, was distilled under reduced pressure. 47.2 g (0.225 mol) of a light yellow liquid were obtained (yield 86.5%). Boiling point=80-82° C./23 mmHg.
References:
US2004/198702,2004,A1 Location in patent:Page 9
