![](/CAS/GIF/4998-07-6.gif)
4,5-Dimethoxy-2-nitrobenzoic acid synthesis
- Product Name:4,5-Dimethoxy-2-nitrobenzoic acid
- CAS Number:4998-07-6
- Molecular formula:C9H9NO6
- Molecular Weight:227.17
![4,5-Dimethoxy-2-nitrobenzoic acid 4,5-Dimethoxy-2-nitrobenzoic acid](/NewsImg/2024-03-27/6384712886691455055283510.png)
![Veratric Acid](/CAS/GIF/93-07-2.gif)
93-07-2
539 suppliers
$5.00/5g
![4,5-Dimethoxy-2-nitrobenzoic acid](/CAS/GIF/4998-07-6.gif)
4998-07-6
223 suppliers
$6.00/5g
Yield:4998-07-6 77%
Reaction Conditions:
with nitric acid in water at 60; for 6 h;Cooling with ice;
Steps:
4.1.12. 3-(3-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxyquinazolin-4(3H)-one (8a)
To a 100 mL flask was added 3,4-dimethoxybenzoic acid (10 g,54.9 mmol) and nitric acid (50 mL, 20%) in an ice-bath. The reactionmixture was then stirred at 60 °C for 6 h. After cooling to rt, themixture was poured onto ice-water. The solid was filtered, washedwith water, dried. The crude was purified by a silica gel column toafford 2-nitro-4,5-dimethoxybenaoic acid as a light yellow solid(9.6 g, yield 77%). mp 195-197 °C; 1H NMR (CDCl3, ppm): d 7.42 (s,1H), 7.26 (s, 1H), 4.03 (s, 3H), 4.02 (s, 3H).
References:
Sun, Yu-Tong;Wang, Gui-Fei;Yang, Yi-Qiu;Jin, Fujun;Wang, Yifei;Xie, Xiao-Yang;Mach, Robert H.;Huang, Yun-Sheng [European Journal of Medicinal Chemistry,2018,vol. 147,p. 227 - 237]
![6-Nitroveratraldehyde](/CAS/GIF/20357-25-9.gif)
20357-25-9
263 suppliers
$5.00/25mg
![4,5-Dimethoxy-2-nitrobenzoic acid](/CAS/GIF/4998-07-6.gif)
4998-07-6
223 suppliers
$6.00/5g
![Methyl 4,5-dimethoxy-2-nitrobenzoate](/CAS/GIF/26791-93-5.gif)
26791-93-5
147 suppliers
$10.00/1g
![4,5-Dimethoxy-2-nitrobenzoic acid](/CAS/GIF/4998-07-6.gif)
4998-07-6
223 suppliers
$6.00/5g
![4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL](/CAS/GIF/1016-58-6.gif)
1016-58-6
158 suppliers
$8.00/1g
![4,5-Dimethoxy-2-nitrobenzoic acid](/CAS/GIF/4998-07-6.gif)
4998-07-6
223 suppliers
$6.00/5g
![Veratraldehyde](/CAS/GIF/120-14-9.gif)
120-14-9
749 suppliers
$5.00/25g
![4,5-Dimethoxy-2-nitrobenzoic acid](/CAS/GIF/4998-07-6.gif)
4998-07-6
223 suppliers
$6.00/5g