ChemicalBook CAS DataBase List 4,5-DIMETHOXY-ISATOIC ANHYDRIDE

4,5-DIMETHOXY-ISATOIC ANHYDRIDE synthesis

9synthesis methods

Product Name:4,5-DIMETHOXY-ISATOIC ANHYDRIDE
CAS Number:20197-92-6
Molecular formula:C10H9NO5
Molecular Weight:223.18

32315-10-9 Synthesis

32315-10-9
410 suppliers
$10.00/1g

5653-40-7 Synthesis

5653-40-7
275 suppliers
$12.50/5 g

20197-92-6
88 suppliers
$15.00/250mg

Yield: 99%

Reaction Conditions:

in tetrahydrofuran at 0; for 5 h;Inert atmosphere;Large scale;

Steps:

4
Under electromagnetic stirring and ice-water bath cooling, respectively add 1d (2000mg, 10.15mmol) and tetrahydrofuran (35mL) to a 150mL round bottom flask, wait for the reaction system to cool, and then slowly add triphosgene (1021mg, 3.45mmol).Under N2 protection, stir for 5h. After the reaction is over, the solvent is removed under reduced pressure, an appropriate amount of petroleum ether is added and sonicated, the precipitated solid is fully suspended in the petroleum ether, and filtered with suction.After drying, 2230 mg of brown solid of compound 2d was obtained (yield 99%).

References:

Guangxi Normal University;Su Guifa;Wang Wang;Pang Li;Xie Ying;Pan Chengxue;Mo Dongliang CN111825679, 2020, A Location in patent:Paragraph 0057-0059