4,5-diMethoxypyridazine synthesis
- Product Name:4,5-diMethoxypyridazine
- CAS Number:55271-48-2
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
2096-22-2
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55271-48-2
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Yield:55271-48-2 43.6%
Reaction Conditions:
with 10 wt% Pd(OH)2/C;hydrogen;triethylamine in ethyl acetate at 25; for 1 h;
Steps:
109.3 Step 3: 4,5-dimethoxypyridazine
To a solution of 3-chloro-4,5-dimethoxypyridazine (600 mg, 3.44 mmol) in EtOAc (20 mL) were added TEA (695 mg, 6.87 mmol) and Pd(OH)2/C (48 mg, 0.03 mmol, 10% wt) and the mixture was degassed under N2 atmosphere for three times and stirred under a H2 balloon at 25 °C for 1 hr. The mixture was filtered and the filtrate was concentrated to dryness to give the title compound (210 mg, 43.6% yield) as white solid. LC/MS (ESI) m/z: 141 (M+H)+. XH NMR (400 MHz, CDCh) 6 8.78 (s, 2H), 3.96 (s, 6H).
References:
WO2022/34568,2022,A1 Location in patent:Paragraph 0446; 0448
2288-74-6
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55271-48-2
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