ChemicalBook CAS DataBase List 4-(5-nitro-H-benzimidazol-2-yl)aniline

4-(5-nitro-H-benzimidazol-2-yl)aniline synthesis

5synthesis methods

Product Name:4-(5-nitro-H-benzimidazol-2-yl)aniline
CAS Number:71002-88-5
Molecular formula:C13H10N4O2
Molecular Weight:254.24

150-13-0 Synthesis

150-13-0
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99-56-9 Synthesis

99-56-9
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71002-88-5
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Yield:71002-88-5 200 mg

Reaction Conditions:

with polyphosphoric acid at 210; for 0.333333 h;

Steps:

8.1 STEP 1

p-Aminobenzoic acid (0.200 g, 1.45 mmol) and nitrophenylene diamine (0.221 g, 1.45 mmol) were added into PPA (30 mL). The mixture was stirred at 210° C. for 20 minutes. Then, it was poured into ice water and extracted with DCM. The organic layer was washed with brine, dried (NaSO₄), filtered and concentrated to afford 200 mg of the desired compound. MS m/z: 255 (M+1).

References:

US2019/127365,2019,A1 Location in patent:Paragraph 0568-0569