4,6-dihydroxybenzofuran-3-one synthesis
- Product Name:4,6-dihydroxybenzofuran-3-one
- CAS Number:3260-49-9
- Molecular formula:C8H6O4
- Molecular Weight:166.13
110865-03-7
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Yield:3260-49-9 88.2%
Reaction Conditions:
with sodium acetate in methanol; for 4 h;Reflux;Inert atmosphere;
Steps:
4.1.2 4.1.2. Synthesis of 4,6-dihydroxybenzofuran-3(2H)-one (5)
Compound 4 (6.25 g) was dissolved in methanol (94 mL) andanhydrous NaOAc (5.34 g, 65.1 mmol) was added. The reactionmixture was then refluxed under argon atmosphere for 4 h. Themethanol was evaporated and the residue was recrystallized fromwater to give compound 5 (4.54 g, 88.2%) as a pale yellow solid.1H NMR (400 MHz, DMSO-d6) d 10.62 (br s, 2H), 5.91 (s, 2H),4.54 (s, 2H). (Data are in agreement with Ref. 28.)
References:
Li, Yan;Qiang, Xiaoming;Luo, Li;Li, Yuxing;Xiao, Ganyuan;Tan, Zhenghuai;Deng, Yong [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 10,p. 2342 - 2351]
91570-58-0
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108-73-6
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$13.00/5g
3260-49-9
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2524-37-0
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$14.00/50mg
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