4,6-dimethylpyridine-2-carbaldehyde synthesis
- Product Name:4,6-dimethylpyridine-2-carbaldehyde
- CAS Number:5439-01-0
- Molecular formula:C8H9NO
- Molecular Weight:135.16
18087-99-5
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Yield:5439-01-0 51%
Reaction Conditions:
with manganese(IV) oxide in chloroform;Heating / reflux;
Steps:
29.b
b) Preparation of 4,6-dimethyl-pyridme-2-carbaldehyde Manganese dioxide (3.17 g, 36.5 mmol) was added to a solution of (4,6- dimethyl-pyridin-2-yl)-methanol (1.0 g, 7.30 mmol) in chloroform (30 mL) and heated at reflux overnight. The reaction mixture was cooled to 0 °C and filtered over celite, washing with further chloroform. The filtrate was evaporated to give a residue which was purified by column chromatography over silica gel (60-120 mesh) using 10 % ethyl acetate in hexane as eluent to afford 4,6-dimethyl-pyridine-2-carbaldehyde (0.5 g, 51 %) as a light brown liquid.
References:
WO2008/62182,2008,A1 Location in patent:Page/Page column 117
7584-11-4
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5439-01-0
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108-75-8
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18088-10-3
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3376-50-9
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