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4-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]MORPHOLINE synthesis

1synthesis methods
110-91-8 Synthesis
Morpholine

110-91-8
677 suppliers
$9.00/1g

39890-95-4 Synthesis
2-Chloro-6-(trifluoromethyl)pyridine

39890-95-4
337 suppliers
$5.00/1g

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Yield:914636-87-6 82%

Reaction Conditions:

with (C5H5)Fe(C5H3C(CH3)NC6H4CH3)PdCl(CN2(C6H3(CH(CH3)2)2)2C2H2);potassium tert-butylate in 1,4-dioxane at 110; for 1 h;Inert atmosphere;Schlenk technique;Buchwald-Hartwig Coupling;

References:

Mu, Bing;Li, Jingya;Wu, Yangjie [Applied Organometallic Chemistry,2013,vol. 27,# 9,p. 537 - 541]