4,7-QUINAZOLINEDIOL DIACETATE synthesis

1synthesis methods

Product Name:4,7-QUINAZOLINEDIOL DIACETATE
CAS Number:849345-41-1
Molecular formula:C12H10N2O4
Molecular Weight:246.22

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Yield:849345-41-1 79%

Reaction Conditions:

with pyridine for 2.5 h;Heating / reflux;

Steps:

9

QUINAZOLINE-4, 7-diol (L. OG, 6. 17MMOL) was suspended in acetic anhydride (8ml) and pyridine (L. 1ml, 1. 42mmol) added. The mixture was heated at reflux for 2. 5H, cooled and carefully poured onto ice/water and stirred for LH The solid was filtered off and dried to give quinazoline-4, 7-diyl diacetate (1g, 79%). 1H NMR spectrum: (DMSO D6) 2.33 (s, 3H); 2.74 (s, 3H); 7.39 (dd, 1H) ; 7.49 (d, 1H); 8.26 (d, 1H); 8.62 (s, 1H).

References:

WO2005/30757,2005,A1 Location in patent:Page/Page column 120