4,8-DICHLORO-QUINAZOLINE synthesis

Yield:-

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide at 72; for 8 h;

Steps:

1.2
A suspension of 8-chloroquinazolin-4(3H)-one (2.74 g, 15.2 mmol) and DMF (200 μL) was heated in thionyl chloride (80 mL) at 72 ⁰C for 8 h, with venting, during which the solution became homogeneous. The solution was slowly added into vigourously stirred ice/water (gas evolution.) and the resulting solid was collected. The solid was washed with water and dried to yield an off-white solid that was used without further purification. MS (ESI) m/z 181.0

References:

WYETH LLC;TRAVINS, Jeremy, Mark;BERNOTAS, Ronald, Charles;WROBEL, Jay, Edward;KAUFMAN, David, Harry;HU, Baihua;JETTER, James, Winfield;O'NEILL, David, John;MANN, Charles, William WO2010/59627, 2010, A1 Location in patent:Page/Page column 50