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4-Acetyl-2-cyanopyridine synthesis

3synthesis methods
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Yield:52689-18-6 53% ,89976-64-7 22%

Reaction Conditions:

Stage #1: methyl (4-pyridyl) ketonewith nitric acid;trifluoroacetic anhydride at 20;
Stage #2: potassium cyanidewith sodium acetate at 20; for 12 h;

References:

Katritzky, Alan R.;Scriven, Eric F. V.;Majumder, Suman;Tu, Hongbin;Vakulenko, Anatoliy V.;Akhmedov, Novruz G.;Murugan, Ramiah [Synthesis,2005,# 6,art. no. M08404SS,p. 993 - 997]

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