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4-acetyl-2-methylbenzoic acid synthesis
- Product Name:4-acetyl-2-methylbenzoic acid
- CAS Number:55860-35-0
- Molecular formula:C10H10O3
- Molecular Weight:178.18
![4-Acetyl-2-methylbenzonitrile](/CAS/20140525/GIF/CB72479625.gif)
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Yield:55860-35-0 84%
Reaction Conditions:
with trifluoroacetic acid at 60; for 12 h;Reagent/catalyst;Temperature;
Steps:
1-3 Preparation of 2-methyl-4-acetylbenzoic acid
1 mmol (1.59 g) of 3-methyl-4-cyanoacetophenone was added to a 100 mL flask.Add 10 ml of trifluoroacetic acid, react at 60 ° C for 12 hours, detect by TLC, after the reaction is completed,Add 10% sodium carbonate melt and adjust to pH 2,It was extracted 3 times with ethyl acetate, and the organic phases were combined, dried and evaporated.Obtained 1.50 g of a beige solid.The yield was 84%.
References:
CN109553528,2019,A Location in patent:Paragraph 0012; 0014; 0016; 0018; 0020; 0022
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![2-METHYLBENZYL TRIPHENYLPHOSPHONIUM BROMIDE](/CAS/GIF/1530-36-5.gif)
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