ChemicalBook CAS DataBase List 4-Acetylbenzonitrile

4-Acetylbenzonitrile synthesis

8synthesis methods

Product Name:4-Acetylbenzonitrile
CAS Number:1443-80-7
Molecular formula:C9H7NO
Molecular Weight:145.16

3032-92-6
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$28.00/1g

1443-80-7
340 suppliers
$6.00/1g

Yield:1443-80-7 92%

Reaction Conditions:

with chloro(1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene)gold(I);water in methanol at 110; for 6 h;

Steps:

15 Example 15 : 4-cyanoacetophenone
The catalyst [(IPr) AuCl] (6.2mg, 1mol%), 4- cyano-phenylacetylene (1mmol), in methanol (1ml) and water (0.5ml) was added successively 25ml reactor.After the reaction mixture was reacted for 6 hours at 110 , cooled to room temperature.Rotary evaporation to remove the solvent, then purified by column chromatography (eluent: petroleum ether / ethyl acetate) to give pure title compound, yield: 92%

References:

Nanjing University of Science and Technology;WANG, NANA;MA, JUAN;LI, FENG CN106032348, 2016, A Location in patent:Paragraph 0083-0086

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