(4-ACETYLPHENYL)PHENYLMETHANE synthesis
- Product Name:(4-ACETYLPHENYL)PHENYLMETHANE
- CAS Number:782-92-3
- Molecular formula:C15H14O
- Molecular Weight:210.27
Yield: 96%
Reaction Conditions:
Stage #1:Diphenylmethane;acetyl chloride with aluminum (III) chloride in dichloromethane at 0 - 20; for 2 h;
Stage #2: with hydrogenchloride
Steps:
1 Example 1
The following is an embodiment of a process for synthesizing a compound represented by formula (6). The first step The following is the first step. [19.1] Materials (1) Anhydrous aluminum chloride: 2.18 g(2) Anhydrous dichloromethane: 35 ml(3) Acetyl chloride: 1.29 g(4) Diphenylmethane: 2.5 gProcess of synthesis Materials (1) and (2) were added to a flask, and the content therein was cooled to 0°C. Material (3) was further added thereto, 15 ml of a dichloromethane solution of material (4) was slowly added dropwise under cooling, and the mixture was stirred at room temperature for 2 hours. Ice (approximately 15 g) was added to the mixture, 20 ml of 1N HCl solution was further added, the precipitated aluminum oxide was allowed to dissolve, and an organic layer was fractionated. An aqueous layer was extracted three times with 20 ml of dichloromethane. The organic layer was mixed and rinsed. Anhydrous magnesium sulfate was added, a solvent was removed by distillation under reduced pressure, and a residue was purified by silica gel chromatography (solvent: n-hexane: ethyl acetate = 3:2) to obtain Compound (a) (yield: 96%).
References:
Hitachi High-Technologies Corporation EP1437338, 2004, A1 Location in patent:Page 13
100-39-0
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782-92-3
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