4-Amino-1-cyclopropylpiperidine synthesis
- Product Name:4-Amino-1-cyclopropylpiperidine
- CAS Number:62813-02-9
- Molecular formula:C8H16N2
- Molecular Weight:140.23
1001345-77-2
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62813-02-9
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$85.00/50mg
Yield:62813-02-9 64%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in methanol at 30; under 3750.38 Torr; for 16 h;
Steps:
N-benzyl-1-cyclopropyl-piperidin-4-amine (Intermediate 25; 2.3 g 10 mmol), 10% Palladium on Carbon (230 mg) and Methanol (230 mL) were combined and heated with stirring at 30° C. under Hydrogen at 5 bar pressure for 16 hours.The mixture was filtered and concentrated, taken up in DCM, dried (MgSO4) and concentrated to give the title compound (1.29 g, 64%) as a yellow liquid1H NMR (399.9 MHz, CDCl3) δ0.36-0.46 (4H, m), 1.26-1.36 (4H, m), 1.52-1.58 (1H, m), 1.76-1.82 (2H, m), 2.18-2.25 (2H, m), 2.63-2.70 (1H, m), 2.94-2.99 (2H, m); MS m/z 161.90 [M+H]+.
References:
US2008/9482,2008,A1 Location in patent:Page/Page column 107
62813-01-8
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62813-02-9
58 suppliers
$85.00/50mg