![](/CAS/20180703/GIF/937049-26-8.gif)
4-Amino-1H-pyrrole-2,4-dicarbonitrile synthesis
- Product Name:4-Amino-1H-pyrrole-2,4-dicarbonitrile
- CAS Number:937049-26-8
- Molecular formula:C6H4N4
- Molecular Weight:132.12
![Pyrrole-2,4-dicarbonitrile](/CAS/20180703/GIF/74023-87-3.gif)
74023-87-3
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![4-Amino-1H-pyrrole-2,4-dicarbonitrile](/CAS/20180703/GIF/937049-26-8.gif)
937049-26-8
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Yield:937049-26-8 82%
Reaction Conditions:
Stage #1: pyrrole-2,4-dicarbonitrilewith O-(diphenylphosphinyl)hydroxylamine;sodium hydride in N,N-dimethyl-formamide at 20 - 80; for 2.25 h;
Stage #2: at 80; for 2 h;
Steps:
AX.2
To a solution of DMF (100 mL) was added lH-pyrrole-2,4-dicarbonitrile (1.00 g, 8.54 mmol) followed by NaH, 60% dispersion in mineral oil (0.51 g, 12.8 mmol). The solution was stirred at rt for 15 min and then (aminooxy)(diphenyl)ρhosphine oxide (2.99 g, 12.8 mmol) was added, and the solution was heated to 80 0C for 2 h. Upon cooling to rt
References:
WO2007/64883,2007,A2 Location in patent:Page/Page column 235-236