ChemicalBook CAS DataBase List 4'-AMINO-2,2':6',2''-TERPYRIDINE

4'-AMINO-2,2':6',2''-TERPYRIDINE synthesis

8synthesis methods

Product Name:4'-AMINO-2,2':6',2''-TERPYRIDINE
CAS Number:193944-66-0
Molecular formula:C15H12N4
Molecular Weight:248.28

39771-34-1 Synthesis

39771-34-1
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193944-66-0
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Yield: 100%

Reaction Conditions:

with bis-triphenylphosphine-palladium(II) chloride;trifuran-2-yl-phosphane in 1,4-dioxaneInert atmosphere;Reflux;

Steps:

92.1 Intermediate 92: Synthesis of 3'-bromo-[2,2':6',2"-tripyridyl]-4'-amine
Step 1: 2-Tri-n-butylstannylpyridine (1.92 g, 5.22 mmol), 4-amino-2,6-dibromopyridine (600 mg, 2.38 mmol),Bis(triphenylphosphine)palladium dichloride (168 mg, 0 · 23 mmol) andA solution of TFP (52 mg, 0.22 mmol) in 1,4-dioxane (20 mL) was stirred under reflux overnight under nitrogen. The reaction mixture was concentrated under reduced pressure.The residue was flash chromatographed (petroleum ether / ethyl acetate = 0/1)Purification afforded [2,2':6',2"-trideinridinyl]-4'-amine (610 mg, yield: 100%) as a yellow solid.

References:

Shanghai Dinuo Pharmaceutical Technology Co., Ltd.;Chen Shoujun;Gao Daxin;Guo Hongli;Chen Tao CN109651358, 2019, A Location in patent:Paragraph 0305; 0306

213674-46-5 Synthesis