ChemicalBook CAS DataBase List 4-amino-3,5-dimethyl-pyrazol

4-amino-3,5-dimethyl-pyrazol synthesis

8synthesis methods

Product Name:4-amino-3,5-dimethyl-pyrazol
CAS Number:5272-86-6
Molecular formula:C5H9N3
Molecular Weight:111.15

14531-55-6 Synthesis

14531-55-6
137 suppliers
$5.00/1g

5272-86-6
59 suppliers
$45.00/100mg

Yield:5272-86-6 86%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethanol under 2250.23 Torr; for 6 h;Autoclave;

Steps:

5.1 Step 1: 3,5-dimethyl-1H-pyrazol-4-amine
3,5-dimethyl-4-nitro-1 H-pyrazole (3.0 g, 21.3 mmol, see international patent application WO 2003057673) was dissolvedin an autoclave in EtOH (50 mL) and added 10% Pd/C (1.0 g). Then 3 bar of H2 were applied to the reaction, which wasstirred for 6 h. The suspension was filtered over celite, washed with EtOH, and the filtrate was concentrated in vacuo.The product (2.0 g, 86%) was crystallized from an EtOH/EtOAc mixture

References:

Deutsches Krebsforschungszentrum;MILLER, Aubry;SCHÜLER, Peter;DE VITA, Elena EP3305781, 2018, A1 Location in patent:Paragraph 0235

FullText