(4-AMINO-3-BROMO-PHENYL)-ACETONITRILE synthesis

2synthesis methods

Product Name:(4-AMINO-3-BROMO-PHENYL)-ACETONITRILE
CAS Number:882855-96-1
Molecular formula:C8H7BrN2
Molecular Weight:211.06

3544-25-0 Synthesis

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Yield:882855-96-1 92%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 0 - 20;

Steps:

52.a

Example 52; 5-Cyano- 1 H-imidazole-2-carboxylic acid [2-(4 j4-dimethyl-cyclohex- 1 -enyl)-4-( 1 H-tetrazol-5 - ylmethyl)-phenyl] -amide; a) (4-Amino-3-bromo-phenyl)-acetonitrile; A solution of 4-aminophenylacetonitrile (1.45 g, 10.9 mmol) in acetonitrile (10 mL) at 0⁰C was treated with NBS (1.95 g, 10.9 mmol) in acetonitrile (10 mL) dropwise via an addition funnel. The reaction was allowed to warm to room temperature and then concentrated in vacuo. The crude product was dissolved in EtOAc (50 mL), washed with saturated aqueous NaHCO₃ (2 x 50 mL) and dried (Na₂SO₄). Removal of the solvent in vacuo afforded the title compound (2.12 g, 92%) as a reddish solid. Mass spectrum (ESI, m/z): Calcd. for C₈H₇BrN₂, 210.9 (M+H), found 211.0.

References:

WO2007/123516,2007,A1 Location in patent:Page/Page column 113-114

555-21-5 Synthesis

555-21-5
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References