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ChemicalBook CAS DataBase List (4-AMino-3-chloro-phenyl)-acetic acid ethyl ester
25814-07-7

(4-AMino-3-chloro-phenyl)-acetic acid ethyl ester synthesis

2synthesis methods
-

Yield:25814-07-7 60%

Reaction Conditions:

Stage #1: ethyl 3-chloro-4-nitrophenylacetatewith stannous chloride dihydrate in ethanol; for 3 h;Reflux;
Stage #2: with sodium hydroxide;water in chloroform at 0; for 0.5 h;

References:

Muro, Fumihito;Iimura, Shin;Yoneda, Yoshiyuki;Chiba, Jun;Watanabe, Toshiyuki;Setoguchi, Masaki;Iigou, Yutaka;Takayama, Gensuke;Yokoyama, Mika;Takashi, Tohru;Nakayama, Atsushi;Machinaga, Nobuo [Bioorganic and Medicinal Chemistry,2008,vol. 16,# 23,p. 9991 - 10000] Location in patent:experimental part

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