4-amino-3-chlorobenzeneacetic acid synthesis

Yield:22106-57-6 86%

Reaction Conditions:

Stage #1: ethyl 4-amino-3-chlorophenylacetatewith water;sodium hydroxide in tetrahydrofuran at 20; for 14 h;
Stage #2: with acetic acid in tetrahydrofuran;water; pH=3 - 4;

References:

Kang, Dong Wook;Kim, Yong Soo;Lim, Kwang Su;Kim, Myeong Seop;Pearce, Larry V.;Pavlyukovets, Vladimir A.;Tao, Andy K.;Lang-Kuhs, Krystle A.;Blumberg, Peter M.;Lee, Jeewoo [Bioorganic and Medicinal Chemistry,2010,vol. 18,# 22,p. 8092 - 8105] Location in patent:experimental part