4-AMINO-3-HYDROXYTETRAHYDROTHIOPHENE, 1,1-DIOXIDE synthesis

Yield:55261-00-2 30%

Reaction Conditions:

with ammonia;water at 20;

Steps:

17.2

Step 2: Compound 17a (0.6Og, 4.48mmol) was added to 26% aqueous ammonia hydroxide (15mL) and the resulting mixture was allowed to stir overnight at r.t. A small amount of solid was filtered off and the filtrate was evaporated to dryness. The residue was triturated with ether, acetone and ethyl acetate, dried to provide compound 17b as white solid (205mg, 30%).

References:

WO2008/33562,2008,A2 Location in patent:Page/Page column 47