(4-AMINO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE synthesis
- Product Name:(4-AMINO-3-NITROPHENYL)(4-FLUOROPHENYL)METHANONE
- CAS Number:31431-26-2
- Molecular formula:C13H9FN2O3
- Molecular Weight:260.22
31431-16-0
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Yield: 96.8%
Reaction Conditions:
with ammonium hydroxide in methanol at 65 - 70; under 2250.23 - 3000.3 Torr; for 4 h;Autoclave;Large scale;
Steps:
2.3 Amination reaction
2387 g of the product5000g methanol,2400g of ammonia (28%) was added to the autoclave.The reaction temperature was controlled at 65-70°C, the reaction pressure was 0.3-0.4 MPa, and the reaction time was about 4 hours. After the reaction was completed, the reaction temperature was lowered to 20° C., filtered, and dried to obtain 2150 g of aminated product (4) with a purity of 97.7% and a yield of 96.8%.
References:
Jiangsu Baozhongbaoda Pharmaceutical Co., Ltd.;Yan Jiaqing;Xia Zhaoliang;Zhang Zhihong CN107698516, 2018, A Location in patent:Paragraph 0037
96-99-1
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38818-50-7
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462-06-6
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