ChemicalBook CAS DataBase List 4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile

4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile synthesis

1synthesis methods

Product Name:4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile
CAS Number:888073-09-4
Molecular formula:C8H4ClF3N2
Molecular Weight:220.58

654-70-6 Synthesis

654-70-6
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4-Amino-5-chloro-2-(trifluoromethyl)benzonitrile

888073-09-4
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Yield:888073-09-4 79%

Reaction Conditions:

with N-chloro-succinimide;α-bromo-α,α-difluoroacetic acid;(4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile in tetrahydrofuran at 20; for 0.5 h;Sealed tube;Inert atmosphere;Irradiation;

References:

Xie, Wuchen;Wang, Meng;Yang, Siyu;Chen, Yadong;Feng, Jie;Huang, Yatian [Organic and Biomolecular Chemistry,2022,vol. 20,# 26,p. 5319 - 5324] Location in patent:supporting information