4-AMINO-5-CHLORO-6-ETHOXYPICOLINIC ACID synthesis
- Product Name:4-AMINO-5-CHLORO-6-ETHOXYPICOLINIC ACID
- CAS Number:904311-15-5
- Molecular formula:C8H9ClN2O3
- Molecular Weight:216.62
894804-33-2
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904311-15-5
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Yield:904311-15-5 70%
Reaction Conditions:
Stage #1: 4-amino-5-chloro-6-ethoxypyridine-2-carboxylic acid methyl esterwith lithium hydroxide;ethanol;water at 20; for 2.5 h;
Stage #2: with hydrogenchloride in water; pH=1;
Steps:
165.165C.B
This material from step A was treated with LiOH in ethanol/water (5:3, 1 M, 2 mL) at ambient temperature for 2 h. HCl(aq) was added after 30 min to adjust pH value to 1. The precipitates were collected to afford the titled compound (130 mg, 70%).
References:
US2006/173050,2006,A1 Location in patent:Page/Page column 63
894803-87-3
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904311-15-5
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