4-amino-5-fluoro-2-methoxybenzoic acid synthesis
- Product Name:4-amino-5-fluoro-2-methoxybenzoic acid
- CAS Number:1346763-78-7
- Molecular formula:C8H8FNO3
- Molecular Weight:185.15
247071-37-0
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1346763-78-7
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Yield:1346763-78-7 68%
Reaction Conditions:
Stage #1: 4-amino-5-fluoro-2-methoxybenzonitrilewith water;potassium hydroxide in ethanol; for 30 h;Reflux;
Stage #2: with dihydrogen peroxide in ethanol;water; for 18 h;Reflux;
References:
Estrada, Anthony A.;Liu, Xingrong;Baker-Glenn, Charles;Beresford, Alan;Burdick, Daniel J.;Chambers, Mark;Chan, Bryan K.;Chen, Huifen;Ding, Xiao;Dipasquale, Antonio G.;Dominguez, Sara L.;Dotson, Jennafer;Drummond, Jason;Flagella, Michael;Flynn, Sean;Fuji, Reina;Gill, Andrew;Gunzner-Toste, Janet;Harris, Seth F.;Heffron, Timothy P.;Kleinheinz, Tracy;Lee, Donna W.;Le Pichon, Claire E.;Lyssikatos, Joseph P.;Medhurst, Andrew D.;Moffat, John G.;Mukund, Susmith;Nash, Kevin;Scearce-Levie, Kimberly;Sheng, Zejuan;Shore, Daniel G.;Tran, Thuy;Trivedi, Naimisha;Wang, Shumei;Zhang, Shuo;Zhang, Xiaolin;Zhao, Guiling;Zhu, Haitao;Sweeney, Zachary K. [Journal of Medicinal Chemistry,2012,vol. 55,# 22,p. 9416 - 9433]
112279-61-5
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1346763-78-7
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