ChemicalBook CAS DataBase List 4-AMINO-6-NITRO-QUINALDINE

4-AMINO-6-NITRO-QUINALDINE synthesis

5synthesis methods

Product Name:4-AMINO-6-NITRO-QUINALDINE
CAS Number:99185-71-4
Molecular formula:C10H9N3O2
Molecular Weight:203.2

1528735-22-9
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99185-71-4
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Yield:99185-71-4 95%

Reaction Conditions:

with triphenylphosphine in tetrahydrofuran at 20; for 0.333333 h;Inert atmosphere;Staudinger Azide Reduction;

Steps:

4-Amino-2-methyl-6-nitroquinoline (14)

To a suspenion of 4-azido-2-methyl-6-nitroquinoline (13; 29.9 g, 130 mmol) in THF (450 mL) was added triphenylphosphine (41.1 g, 160 mmol). The resulting solution was stirred at room temperature for 20 min and water (45 mL) was added. The solution was evaporated to ~200 mL total volume, then poured into 2.5 M aqueous HCl (1.5 L) and stirred vigorously until the solids had completely dissolved. The aqueous solution was extracted with Et₂O (250 mL × 3), and the aqueous solution was adjusted to pH 9 with 50% aqueous NaOH solution. The resulting bright yellow crystalline solid was collected by filtration, washed with cold water (500 mL), and dried to provide 25.2 g (95%) of product as a bright yellow crystalline solid: mp >250 °C; R_f 0.37 (95:4.5:0.5 CHCl₃:MeOH:aq. MeNH₂); ¹H-NMR (DMSO-d₆) δ 9.22 (d, 1H), 8.25 (dd, 1h), 7.77 (d, 1H), 7.30 (s, br, 2H), 6.55 (s, 1H), 2.45 (s, 3H).

References:

Williams, John D.;Khan, Atiyya R.;Cardinale, Steven C.;Butler, Michelle M.;Bowlin, Terry L.;Peet, Norton P. [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 419 - 434] Location in patent:supporting information

17420-30-3 Synthesis