4-[(anilinocarbonothioyl)amino]benzenesulfonamide synthesis
1synthesis methods
- Product Name:4-[(anilinocarbonothioyl)amino]benzenesulfonamide
- CAS Number:4474-05-9
- Molecular formula:C13H13N3O2S2
- Molecular Weight:307.39
Yield:4474-05-9 80%
Reaction Conditions:
in 1,4-dioxane;N,N-dimethyl-formamide; for 1 h;
Steps:
N,N'-disubstituted thioureas (2a-d)
General procedure: A mixture of appropriate sulfonamide 1 (10 mmol) in DMF (20 mL) and the appropriate isothiocyanate (10 mmol) in dioxin (20 mL) was heated on a water bath for 1 h, cooled and then poured onto ice cooled water. The pale yellow solid thus obtained was filtered and recrystallized from ethanol as needles.
References:
Faidallah, Hassan M.;Khan, Khalid A. [Journal of Fluorine Chemistry,2012,vol. 142,p. 96 - 104]