4-benzoyl-2-chloronicotinonitrile synthesis
1synthesis methods
- Product Name:4-benzoyl-2-chloronicotinonitrile
- CAS Number:1194341-12-2
- Molecular formula:C13H7ClN2O
- Molecular Weight:242.66
Yield:1194341-12-2 71%
Reaction Conditions:
Stage #1: 2-chloro-3-pyridinecarbonitrilewith (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl2*4LiCl in tetrahydrofuran at 0; for 0.75 h;Inert atmosphere;
Stage #2: benzoyl chloridewith copper(I) cyanide di(lithium chloride) in tetrahydrofuran at -30 - 0;Inert atmosphere;chemospecific reaction;
References:
Wunderlich, Stefan H.;Kienle, Marcel;Knochel, Paul [Angewandte Chemie - International Edition,2009,vol. 48,# 39,p. 7256 - 7260][Angewandte Chemie,2009,vol. 121,# 39,p. 7392 - 7396] Location in patent:supporting information; experimental part